‘Genome’ doesn’t cover it: Introducing Gene Systems Hypothesis and Functional Gene Systems
James O. Fredrickson
23 May 2014
24 May 2017
12 Jun 2017
symbiosis, systems biology, mutualism, emergent, phenotype
Traditionally, the genes which contribute to the phenotype of a eukaryotic organism were considered to be housed within its nuclear genome, but today this is often understood to not be the case. In order to better understand how high-level complex phenotypic expressions arise I propose a conceptual framework composed of core systems biology ideas integrated with current understanding of genetic systems: gene systems hypothesis (GSH). The implications of this GSH framework allow for an organism level functional gene system (O-FGS) definition which incorporates the integration of macro- and micro-symbiont gene systems. In support of the proposed O-FGS definition a brief review of current literature is presented which demonstrates the influence of micro- and macro-symbionts in plant and animal development, growth and persistence.